Smoky Chipotle Glazed Meatloaf with Cheddar-Stuffed Center

OPRA MIXES
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A bold twist on the classic comfort food—juicy, cheesy, and packed with smoky-sweet heat.


Why This Isn’t Your Average 

Let’s be honest—meatloaf has a reputation problem. For many, it conjures up dry, bland slices from a school cafeteria or a too-ketchup-y dinner from childhood. But this version? It's the redemption arc.

We’re taking everything you think you know about meatloaf and flipping it. Think smoky chipotle glaze, a melty cheddar-stuffed center, and a moist, flavorful meat mixture that holds its shape and never dries out. It's a weeknight meal with serious flavor—just as good for a Sunday dinner or meal prep for the week.


Ingredients You’ll Need

This recipe keeps things simple, but smart. We’re building flavor from the inside out.

For the Meatloaf:

  • 1 ½ lbs ground beef (80/20 recommended)

  • ½ lb ground pork (adds richness)

  • 1 small yellow onion, finely chopped

  • 3 cloves garlic, minced

  • 1 egg

  • ¾ cup plain breadcrumbs

  • ⅓ cup whole milk

  • 1 tbsp Worcestershire sauce

  • 1 tsp smoked paprika

  • ½ tsp cumin

  • ½ tsp salt

  • ½ tsp black pepper

  • 1 cup shredded sharp cheddar cheese

For the Chipotle Glaze:

  • ¼ cup ketchup

  • 1 tbsp adobo sauce (from a can of chipotle peppers)

  • 1 tbsp brown sugar

  • 1 tsp apple cider vinegar

  • Optional: ½ chopped chipotle pepper for more heat


Step-by-Step Instructions

Here’s how to get meatloaf that’s flavorful, juicy, and never boring.


1. Preheat and Prep

Preheat your oven to 375°F (190°C). Line a baking sheet with foil or parchment, or use a loaf pan if you prefer more height to your loaf.


2. Sauté the Aromatics

In a small skillet, cook the chopped onion and garlic over medium heat with a drizzle of olive oil until soft and slightly golden (about 5 minutes). This step mellows the bite and boosts flavor. Let cool slightly before adding to the meat mixture.


3. Mix the Meatloaf Base

In a large mixing bowl, combine:

  • Ground beef and pork

  • Sautéed onion and garlic

  • Egg

  • Milk

  • Breadcrumbs

  • Worcestershire sauce

  • Spices (paprika, cumin, salt, pepper)

Mix gently with your hands or a spatula—just until combined. Overmixing = tough meatloaf.


4. Form and Stuff

On your prepared baking sheet or board:

  • Flatten half the meat mixture into a thick rectangle

  • Sprinkle the cheddar cheese down the center

  • Top with the remaining meat, sealing the edges so the cheese is completely tucked in

Pro tip: Lightly damp hands make shaping much easier.


5. Make the Glaze

In a small bowl, whisk together:

  • Ketchup

  • Adobo sauce

  • Brown sugar

  • Vinegar

  • (Optional) Finely chopped chipotle for heat

Spoon half the glaze over the loaf before baking for that sticky-sweet crust.


6. Bake It

Bake the meatloaf for 45–55 minutes, or until the internal temperature reaches 160°F (71°C).

In the last 10 minutes, brush on the rest of the glaze and return to the oven so it caramelizes.


7. Rest Before Slicing

Let the meatloaf rest for 10 minutes before slicing. This helps all those delicious juices settle back in—and prevents it from crumbling apart.


Serving Ideas

This meatloaf pairs beautifully with:

  • Garlic mashed potatoes

  • Roasted carrots or green beans

  • A simple slaw or arugula salad to balance the richness

And let’s be real: leftover meatloaf sandwiches with chipotle mayo on sourdough? Chef’s kiss.


Tips for Success

  • Don’t skip the pork. It adds fat and flavor that keeps the loaf juicy.

  • Breadcrumbs + milk = tender texture. This panade is the secret to moisture.

  • Use a thermometer. Don’t guess doneness—hit 160°F and you’re golden.

  • Rest it. Just like steak, it makes a big difference.


Why You’ll Come Back to This Recipe

This meatloaf hits that perfect balance between comfort and character. It’s warm and familiar, but not predictable. The cheddar center is a fun surprise, and the smoky glaze gives it just enough edge.

It’s easy enough for a weeknight and satisfying enough for guests. And best of all, it reheats like a dream—so you’ve got lunch for days.


🍴 Let’s Cook

Try it once, and this will be your new go-to meatloaf. Feel free to add your own spin—swap the cheese, tweak the glaze, or throw in chopped jalapeños for more heat.

Tag your version on Instagram or drop a comment—I'd love to see how you make it yours.



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